Indiana enters as a 6-0, top-5 program with zero starters ruled out, while Ohio State is missing starting OT Austin Siereveld and RB Ja'Kobi Jackson (354 rushing yards, 6 TDs on the season) — a significant personnel deficit for a team already carrying a season-opening loss. The Hoosiers are riding a 23-game winning streak at home in Bloomington with a motivated, healthy squad, making Indiana +3.0 an exceptional number to grab against a shorthanded Buckeye offense.