Clemson is a blue-blood program hosting a FCS-level Charleston Southern squad at Death Valley, and even at 3-2 the Tigers still boast the roster talent and home-field edge to blow out inferior competition by 50+. Charleston Southern has no business being on the same field as an ACC program, and Dabo Swinney's teams routinely cover massive spreads in these cupcake tune-up games. Talent wins, and the talent gap here is a canyon — Clemson -43.5 is the obvious lock.