Indiana's injury report is severely compromised heading into this matchup: Tyrese Haliburton (their primary playmaker, 9.5 APG) is questionable with hamstring tightness, Andrew Nembhard is also questionable, and Ben Sheppard is out. Philadelphia's defense ranks 7th in points allowed per game, and Tyrese Maxey is averaging 28.8 PPG — the Sixers have the firepower to exploit a shorthanded Pacers squad. With Indiana's backcourt depth gutted, Philadelphia's -4.5 spread is very coverable on the road.